Maternal Thyroid hormone: a strong repressor of neuronal nitric oxide synthase (nNOS) in rat embryonic neocortex Short Title: Maternal thyroxine and nNOS expression

نویسندگان

  • Rohit Anthony Sinha
  • Amrita Pathak
  • Vishwa Mohan
  • Sanghamitra Bandyopadhyay
  • Leena Rastogi
  • Madan M Godbole
  • Sanjay Gandhi
  • Madan M. Godbole
چکیده

This work was supported by grant from Department of Science & Technology (DST), Govt. of India through F.I.S.T. SR/SO/HS/17/2003 and SR/SO/HS/95/2007 to MMG and Senior Research Fellowship from Council of Scientific and Industrial Research to RAS [10-2(5)/2003(II)-E.U.II] and University Grants Commission to AP [2-89/98(SA-I)] from Government of India, New Delhi. Endocrinology. First published ahead of print May 8, 2008 as doi:10.1210/en.2007-1617

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Role of matrix metalloproteinase II on analgesic effect of nitric oxide inhibition in rat

Abstract Introduction: Matrix metalloproteinase 2 is one of the inflammatory mediators that is involved in nociceptive processing and its production is regulated by many inflammatory factors such as nitric oxide. We studied the role of MMP-2 on the analgesic effects of nNOS inhibitor. Methods: Considering that nitric oxide has many roles in pain processing, we studied the CSF levels of MMP-2 ...

متن کامل

Effect of Severe Hyperthyroidism on Concentrations of Nitric Oxide-producing Enzymes in Liver of Male Rats

Introduction: Thyroid hormones play an important role in normal function of liver and hyperthyroidism can cause liver dysfunction. Thyroid hormones affect nitric oxide (NO)-producing enzymes in liver. The aim of this study is to investigate effects of hyperthyroidism on protein levels of three isoforms of NO synthase (NOS) enzymes, including endothelial NOS (eNOS), inducible NOS (iNOS), and neu...

متن کامل

P2: The Role of Neuronal Nitric Oxide Synthase on the Anti-Seizure Effects of 5-HT1A Receptors in Perforant Pathway Kindling Model in Rat

Neuronal nitric oxide synthase (nNOS) plays a role in synaptic potentiation and kindling process.The relationship between nNOS and 5-HT1A receptors also nearly has been specified. In this research,we investigate the role of nNOS on the anticonvulsant effect of 5-HT1A receptors. 24 male (280 ± 30 g) were randomly assigned to four groups (vehicle,NI,Way 100635 and NI + Way100635) (n = 6). ...

متن کامل

NMDAR1 glutamate receptor subunit isoforms in neostriatal, neocortical, and hippocampal nitric oxide synthase neurons.

Nitric oxide (NO), an unconventional and diffusible neurotransmitter, is synthesized by nitric oxide synthase (NOS). NMDA glutamate receptors are potent regulators of NO synthesis. We have used dual-label immunofluorescence and confocal microscopy to examine forebrain neurons in the rat that contain high levels of neuronal NOS (nNOS) for the presence of the NMDAR1 receptor subunit protein and r...

متن کامل

Multiple embryonic origins of nitric oxide synthase-expressing GABAergic neurons of the neocortex

CORTICAL GABAERGIC INTERNEURONS IN RODENTS ORIGINATE IN THREE SUBCORTICAL REGIONS: the medial ganglionic eminence (MGE), the lateral/caudal ganglionic eminence (LGE/CGE), and the preoptic area (POA). Each of these neuroepithelial precursor domains contributes different interneuron subtypes to the cortex. Neuronal NOS (nNOS)-expressing neurons represent a heterogenous population of cortical inte...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2008